GrippeAllemagneV3, Main, Exploration, bibRecord, 000170

Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany.

Identifieur interne : 000170 ( Main/Exploration ); précédent : 000169; suivant : 000171

Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany.

Auteurs : Janine Reiche [Allemagne] ; Sonja Jacobsen [Allemagne] ; Katrin Neubauer [Allemagne] ; Susi Hafemann [Allemagne] ; Andreas Nitsche [Allemagne] ; Jeanette Milde [Allemagne] ; Thorsten Wolff [Allemagne] ; Brunhilde Schweiger [Allemagne]

Source :

PloS one [ 1932-6203 ] ; 2014.

RBID : pubmed:24505479

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Allemagne (épidémiologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections de l'appareil respiratoire (épidémiologie), Infections à Paramyxoviridae (épidémiologie), Jeune adulte, Metapneumovirus (génétique), Metapneumovirus (isolement et purification), Mâle, Nourrisson, Phylogénie, RT-PCR, Variation génétique, Épidémiologie moléculaire.
MESH :
- génétique : Metapneumovirus.
- isolement et purification : Metapneumovirus.
- épidémiologie : Allemagne, Infections de l'appareil respiratoire, Infections à Paramyxoviridae.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Phylogénie, RT-PCR, Variation génétique, Épidémiologie moléculaire.
Wicri :
- geographic : Allemagne.

English descriptors

KwdEn :
- Adolescent, Adult, Child, Child, Preschool, Female, Genetic Variation, Germany (epidemiology), Humans, Infant, Male, Metapneumovirus (genetics), Metapneumovirus (isolation & purification), Middle Aged, Molecular Epidemiology, Paramyxoviridae Infections (epidemiology), Phylogeny, Respiratory Tract Infections (epidemiology), Reverse Transcriptase Polymerase Chain Reaction, Young Adult.
MESH :
- geographic , epidemiology : Germany.
- epidemiology : Paramyxoviridae Infections, Respiratory Tract Infections.
- genetics : Metapneumovirus.
- isolation & purification : Metapneumovirus.
- Adolescent, Adult, Child, Child, Preschool, Female, Genetic Variation, Humans, Infant, Male, Middle Aged, Molecular Epidemiology, Phylogeny, Reverse Transcriptase Polymerase Chain Reaction, Young Adult.

Abstract

Human metapneumovirus (HMPV) is a cause of respiratory tract illness at all ages. In this study the epidemiological and molecular diversity among patients of different ages was investigated. Between 2000-2001 and 2009-2010, HMPV was detected in 3% (138/4,549) of samples from outpatients with influenza-like illness with a new, sensitive real-time RT-PCR assay. Several hundred (797) clinical specimens from hospitalized children below the age of 4 years with acute respiratory illness were investigated and HMPV was detected in 11.9% of them. Investigation of outpatients revealed that HMPV infections occurred in individuals of all ages but were most prevalent in children (0-4 years) and the elderly (>60 years). The most present clinical features of HMPV infections were cough, bronchitis, fever/shivers and pneumonia. About two thirds of HMPV-positive samples were detected in February and March throughout the study period. Molecular characterization of HMPV revealed a complex cyclic pattern of group dominance where HMPV subgroup A and B viruses predominated in general for three consecutive seasons. German HMPV represented all genetic lineages including A1, A2, B1, B2, sub-clusters A2a and A2b. For Germany, not only time-dependent circulation of lineages and sub-clusters was observed but also co-circulation of two or three predominant lineages. Two newly emerging amino acid substitutions (positions 223 and 280) of lineage B2 were detected in seven German HMPV sequences. Our study gives new insights into the molecular epidemiology of HMPV in in- and outpatients over a time period of 10 years for the first time. It is one of only few long-term surveillance studies in Europe, and allows comparative molecular analyses of HMPV circulating worldwide.

DOI: 10.1371/journal.pone.0088342
PubMed: 24505479

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Human metapneumovirus (HMPV) is a cause of respiratory tract illness at all ages. In this study the epidemiological and molecular diversity among patients of different ages was investigated. Between 2000-2001 and 2009-2010, HMPV was detected in 3% (138/4,549) of samples from outpatients with influenza-like illness with a new, sensitive real-time RT-PCR assay. Several hundred (797) clinical specimens from hospitalized children below the age of 4 years with acute respiratory illness were investigated and HMPV was detected in 11.9% of them. Investigation of outpatients revealed that HMPV infections occurred in individuals of all ages but were most prevalent in children (0-4 years) and the elderly (>60 years). The most present clinical features of HMPV infections were cough, bronchitis, fever/shivers and pneumonia. About two thirds of HMPV-positive samples were detected in February and March throughout the study period. Molecular characterization of HMPV revealed a complex cyclic pattern of group dominance where HMPV subgroup A and B viruses predominated in general for three consecutive seasons. German HMPV represented all genetic lineages including A1, A2, B1, B2, sub-clusters A2a and A2b. For Germany, not only time-dependent circulation of lineages and sub-clusters was observed but also co-circulation of two or three predominant lineages. Two newly emerging amino acid substitutions (positions 223 and 280) of lineage B2 were detected in seven German HMPV sequences. Our study gives new insights into the molecular epidemiology of HMPV in in- and outpatients over a time period of 10 years for the first time. It is one of only few long-term surveillance studies in Europe, and allows comparative molecular analyses of HMPV circulating worldwide. </div>
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<DateCompleted><Year>2014</Year>
<Month>09</Month>
<Day>29</Day>
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<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>05</Day>
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<PubDate><Year>2014</Year>
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<Title>PloS one</Title>
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<ArticleTitle>Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany.</ArticleTitle>
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<Abstract><AbstractText>Human metapneumovirus (HMPV) is a cause of respiratory tract illness at all ages. In this study the epidemiological and molecular diversity among patients of different ages was investigated. Between 2000-2001 and 2009-2010, HMPV was detected in 3% (138/4,549) of samples from outpatients with influenza-like illness with a new, sensitive real-time RT-PCR assay. Several hundred (797) clinical specimens from hospitalized children below the age of 4 years with acute respiratory illness were investigated and HMPV was detected in 11.9% of them. Investigation of outpatients revealed that HMPV infections occurred in individuals of all ages but were most prevalent in children (0-4 years) and the elderly (>60 years). The most present clinical features of HMPV infections were cough, bronchitis, fever/shivers and pneumonia. About two thirds of HMPV-positive samples were detected in February and March throughout the study period. Molecular characterization of HMPV revealed a complex cyclic pattern of group dominance where HMPV subgroup A and B viruses predominated in general for three consecutive seasons. German HMPV represented all genetic lineages including A1, A2, B1, B2, sub-clusters A2a and A2b. For Germany, not only time-dependent circulation of lineages and sub-clusters was observed but also co-circulation of two or three predominant lineages. Two newly emerging amino acid substitutions (positions 223 and 280) of lineage B2 were detected in seven German HMPV sequences. Our study gives new insights into the molecular epidemiology of HMPV in in- and outpatients over a time period of 10 years for the first time. It is one of only few long-term surveillance studies in Europe, and allows comparative molecular analyses of HMPV circulating worldwide. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reiche</LastName>
<ForeName>Janine</ForeName>
<Initials>J</Initials>
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<ForeName>Sonja</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Influenza Viruses and Other Respiratory Viruses, National Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Neubauer</LastName>
<ForeName>Katrin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Division of Influenza Viruses and Other Respiratory Viruses, National Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany.</Affiliation>
</AffiliationInfo>
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<ForeName>Susi</ForeName>
<Initials>S</Initials>
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<ForeName>Andreas</ForeName>
<Initials>A</Initials>
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<Author ValidYN="Y"><LastName>Milde</LastName>
<ForeName>Jeanette</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Division of Influenza Viruses and Other Respiratory Viruses, National Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Wolff</LastName>
<ForeName>Thorsten</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Division of Influenza Viruses and Other Respiratory Viruses, National Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Schweiger</LastName>
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<ArticleIdList><ArticleId IdType="pubmed">24505479</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0088342</ArticleId>
<ArticleId IdType="pii">PONE-D-13-34286</ArticleId>
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<ReferenceList><Reference><Citation>Arch Intern Med. 2008 Dec 8;168(22):2489-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19064834</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2003 Jul;41(7):3043-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12843040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2008 May;80(5):902-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18360903</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2003 Jul;41(7):2987-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12843031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2006 Jun 15;193(12):1630-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16703505</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2013 Mar;85(3):546-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23296388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2003 Jun;9(6):634-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12781001</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Infect Dis J. 2008 Dec;27(12):1065-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18978517</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2003 May;93(1):51-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12727342</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Rev. 2011 Oct;24(4):734-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21976607</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Infect Dis J. 2008 Oct;27(10 Suppl):S80-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18820584</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Rev. 2006 Jul;19(3):546-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16847085</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2012 Aug;50(8):2714-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22692746</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2002 Nov 1;186(9):1330-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12402203</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2006 Aug;44(8):2739-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16891486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2011 Oct;83(10):1799-810</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21837798</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2004 Dec 1;190(11):1913-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15529254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2004 Jan 29;350(5):431-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14749447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2006 Apr;35(4):394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16460998</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2009 Feb;81(2):340-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19107972</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2003 Oct;41(10):4642-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14532196</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2003 Jun;70(2):281-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12696118</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2005 Jul;11(7):1074-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16022783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2006 Feb 20;345(2):492-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16300813</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2012 Jul 1;206(1):56-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22529314</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2005 Nov;150(11):2365-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15986171</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2004 Jun;10(6):1095-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15207063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2008 Sep;80(9):1631-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18649344</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2003 Oct 10;315(1):1-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14592754</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2004 Apr 1;38(7):983-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15034830</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2010 Mar 04;15(9):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20214868</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatrics. 2003 Jun;111(6 Pt 1):1407-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12777560</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2008 Jul;80(7):1282-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18461619</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2008 Jul;42(3):273-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18455957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2009 May;81(5):915-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19319957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2004 Jan 29;350(5):443-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14749452</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Syst Biol. 2003 Oct;52(5):696-704</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14530136</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Nov;80(22):10931-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16971452</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2010 Oct;82(10):1782-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20827777</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2001 Jun;7(6):719-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11385510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2009;154(11):1831-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19774338</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2004 Apr;10(4):658-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15200856</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virol J. 2009 Sep 09;6:138</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19740442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2003 Jun;9(6):628-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12781000</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biosci. 2008 Nov;33(4):483-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19208974</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2005 Jan;75(1):101-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15543589</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2004 Jun;10(6):1154-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15207075</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2002 Sep;8(9):897-901</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12194763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2006 Jan;12(1):147-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16494734</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany.

Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany.

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